ea0059oc5.1 | Adrenal | SFEBES2018
Prete Alessandro
, Taylor Angela E
, Schiffer Lina
, Nestola Manuela
, Pignata Luisa
, Corsello Salvatore M
, Arlt Wiebke
Background: Cushings syndrome (CS) is caused by endogenous cortisol excess and is associated with significant morbidity. Twenty-four-hour urinary cortisol is one of the most useful tools to diagnose CS although it has limitations, especially in mild and subclinical forms of cortisol excess. We hypothesized that given the diurnal rhythm of physiological cortisol secretion, night-time urinary glucocorticoid excretion should be lower than day-time ex...